This paper studies the effects of changes in states’ scope of practice laws (SOP) for advanced practice registered nurses (APRNs) on individual labor supply decisions. Restrictive SOP impose costs and other barriers to practice that may affect these decisions. Using survey data on APRNs, we analyze employment in nursing, work hours, part-time work status, multiple job holding, self-employment, wages, and migration. Results show that the level of SOP restrictions are not strong determinants of many labor market decisions, with a few exceptions. We find that hours worked and self-employment both increase when nurses practice in regulatory environments that are free from physician oversight requirements.